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KMID : 1123920100240010048
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Korean Journal of Oriental Physiology and Pathology
2010 Volume.24 No. 1 p.48 ~ p.54
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Inhibitory Effect of Saingheylyunbooem on Compound 48/80 Stimulated Allergic Reaction
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Kim Hee-Yeol
Park Jong-Hyun
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Abstract
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The present study was conducted to investigate the anti-allergic activity of Saingheylyunbooem(SHU)). We investigated the anti-allergic effects of SHU in RBL-2H3 basophilic leukemia cells by compound 48/80, a mast cell degranulator in mice. SHU inhibited -hexosaminidase and histamine release from compound 48/80 stimulated RBL-2H3 cells. The in vitro anti-inflammatory activities of SHU in LPS-stimulated RAW 264.7 cells were investigated. SHU inhibited NO production effectively dowregulated the expression of iNOS mRNA and iNOS protein expression in LPS-stimulated RAW 264.7 cells. These result provide evidences that SHU may be beneficial in the treatment of allergic inflammtory disease.
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KEYWORD
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Saingheylyunbooem(SHU), allergy, compound 48/80, β-hexosaminidase, histamine release, nitric oxide
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